What are the toxicological implications of ADP-Ribosylhydrolase dysfunction?
Dysfunction in ADP-Ribosylhydrolases can have profound toxicological implications. For instance, impaired hydrolase activity can lead to excessive ADP-ribosylation, disrupting normal cellular processes and potentially leading to cell death. This can result in increased sensitivity to toxins and contribute to the development of diseases such as cancer. Additionally, some bacterial toxins exploit ADP-ribosylation to modify host cell proteins, and defects in hydrolase activity can exacerbate these effects, leading to severe pathogenic outcomes.
