How do ADP-Ribosylhydrolases interact with DNA damage repair mechanisms?
One key role of ADP-Ribosylhydrolases is in the repair of DNA damage. When cells are exposed to toxicants, such as ionizing radiation or chemical mutagens, DNA strand breaks often occur. ADP-ribosylation of proteins involved in the DNA repair pathways is a critical step in signaling and initiating repair. Hydrolases ensure the timely removal of ADP-ribose groups, allowing repair proteins to dissociate and effectively conclude the repair process, thus maintaining cellular integrity.
