What are the Toxicological Implications of Lipid II Targeting?
Targeting lipid II presents several toxicological advantages. Because lipid II is absent in human cells, drugs that specifically target this molecule tend to exhibit low toxicity to human tissues. However, the overuse or misuse of such antibiotics can lead to antibiotic resistance, a significant public health concern. Resistance mechanisms often involve alterations in the structure of lipid II or the use of alternative pathways for cell wall synthesis, necessitating continuous research to stay ahead of resistant bacterial strains.
