What Are the Toxicological Implications of Untreated PKU?
Untreated PKU can result in severe neurological damage due to the toxic effects of elevated phenylalanine. This can include permanent intellectual disability, microcephaly, and neuropsychiatric disorders. Toxicological research has focused on understanding the mechanisms by which phenylalanine exerts its harmful effects, as well as the long-term outcomes of sustained high levels.
