Safety evaluation employs a variety of methods and tools, including:
In Vitro Testing: Laboratory-based methods that use cell cultures to study the toxic effects of substances without involving live animals. In Vivo Testing: Studies conducted in live animals to assess the systemic effects of substances, providing data that is often more applicable to humans. Computational Modeling: Techniques such as QSAR (Quantitative Structure-Activity Relationship) models that predict the toxicological properties based on chemical structure. Human Epidemiological Studies: Research analyzing the effects of substances on human populations, often used to confirm findings from animal studies.