There are several types of pharmacokinetic models used in toxicology, including:
Compartmental models: These models divide the body into compartments where the drug is assumed to be uniformly distributed. The simplest form is the one-compartment model, where the body is seen as a single, homogeneous unit. More complex models, like the two-compartment model, account for different rates of distribution and elimination between compartments. Physiologically Based Pharmacokinetic (PBPK) models: These models are more detailed and attempt to simulate the actual biological systems of the body. They are based on the anatomy and physiology of the organism, offering a more accurate representation of biological processes. Non-compartmental models: These models do not assume a specific compartmental structure and are based on statistical methods to analyze the data. They are often used when the underlying biological processes are too complex to be captured by simple compartmental models.
