The primary cause of carotenodermia is the excessive consumption of carotenoid-rich foods, such as carrots, sweet potatoes, and pumpkins. Carotenoids are fat-soluble pigments found in plants that contribute to their vivid colors and are precursors to vitamin A. While these compounds are not toxic, their accumulation in the skin causes a noticeable color change. Unlike other toxic responses, carotenodermia results from dietary choices rather than exposure to harmful chemicals.