There are several factors that can contribute to intolerance:
Genetic factors: Genetic variations can affect how drugs are metabolized, leading to increased sensitivity. Enzyme deficiencies: Lack of specific enzymes can lead to the accumulation of toxic metabolites. Drug interactions: Concurrent use of multiple drugs can exacerbate sensitivity to particular substances. Pre-existing conditions: Conditions such as liver or kidney disease can alter the metabolism and clearance of drugs.
