Iron accumulation can arise from excessive iron intake, whether through diet, supplements, or therapeutic interventions, such as blood transfusions. Certain genetic disorders, like hereditary hemochromatosis, can also lead to increased intestinal iron absorption. In addition, conditions such as chronic liver disease or ineffective erythropoiesis can contribute to iron overload. Each of these factors can disrupt the body's ability to maintain iron homeostasis, leading to toxic levels of iron in the body.
