Over anticoagulation typically results from the use of vitamin K antagonists like warfarin, as well as newer anticoagulants, such as direct oral anticoagulants (DOACs). Several factors can contribute to this condition:
Drug interactions: Certain medications can potentiate the effect of anticoagulants, leading to excessive anticoagulation. Examples include antibiotics, antifungals, and certain herbal supplements. Dietary interactions: Foods high in vitamin K, such as leafy greens, can affect the anticoagulant effect of warfarin, making its management challenging. Genetic factors: Genetic polymorphisms can alter the metabolism of anticoagulants, leading to variable patient responses. Renal and hepatic impairment: Impaired organ function can affect drug metabolism and elimination, increasing the risk of over anticoagulation.
