Management of over anticoagulation depends on the severity of the condition and the specific anticoagulant involved:
For warfarin: Mild cases with an elevated INR but no bleeding may be managed by temporarily withholding the drug and monitoring the INR. In cases of major bleeding, administration of vitamin K and prothrombin complex concentrates (PCC) or fresh frozen plasma (FFP) may be necessary to rapidly reverse anticoagulation. For DOACs: The management includes using specific reversal agents such as idarucizumab for dabigatran or andexanet alfa for factor Xa inhibitors. In the absence of these agents, supportive care and symptomatic treatment are essential.
