The pancreas plays a crucial role in digestion by secreting enzymes that help break down carbohydrates, fats, and proteins. Toxic substances can adversely affect pancreatic function. Chronic exposure to alcohol, for instance, is well-known for causing pancreatitis, which can lead to pancreatic insufficiency. Furthermore, certain toxins, such as cigarette smoke and specific industrial chemicals, have been linked to pancreatic damage and increased risk of insufficiency.