modes of action

What Challenges Exist in Characterizing Mode of Action?

One of the main challenges in characterizing MoA is the complexity of biological systems and the multifactorial nature of toxic effects. Different species may exhibit different MoAs for the same chemical, complicating the extrapolation of animal data to humans. Additionally, low-dose exposures and the cumulative effects of multiple chemicals present further difficulties in delineating specific MoAs.

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