What Challenges Exist in Targeting Protein Kinases in Toxicology?
Despite their potential, targeting protein kinases in toxicology presents challenges. One major issue is the specificity of kinase inhibitors, as many kinases share similar structures. Off-target effects can lead to unintended consequences, complicating therapeutic interventions. Additionally, the development of resistance to kinase inhibitors is a significant hurdle, often requiring combination therapies or novel inhibitor designs.
