What Role Do Protein Kinases Play in Toxicant-Induced Diseases?
Many diseases induced by toxicants, such as cancer, neurodegenerative disorders, and metabolic diseases, involve dysregulated kinase activity. For example, chronic exposure to certain carcinogens can lead to the activation of kinases that promote cell proliferation and inhibit apoptosis, facilitating tumorigenesis. Similarly, neurotoxins may alter kinase signaling in neurons, contributing to neurodegenerative diseases.
