Several factors influence the calculation of the ARfD, including:
- Species Differences: The response to chemicals can vary significantly between species, requiring adjustments. - Sensitivity Across Populations: Variations in sensitivity among different human populations, such as children, pregnant women, and the elderly, are considered. - Chemical Properties: The nature and mechanism of action of the chemical influence the assessment. - Data Quality: The reliability and completeness of available data play a critical role in determining the ARfD.
