Several factors influence dermal absorption, including:
Chemical Properties: Lipophilic (fat-soluble) substances penetrate the skin more easily than hydrophilic (water-soluble) substances. Skin Condition: Damaged or diseased skin can allow greater absorption of chemicals. Exposure Duration: Longer exposure times generally increase the amount of chemical absorbed. Concentration: Higher concentrations of a chemical can enhance its absorption through the skin. Body Site: Different areas of the body have varying thicknesses of the stratum corneum, affecting absorption rates.
