Several factors can affect the efficiency and extent of glucuronidation:
Genetic Variability: Differences in UGT enzyme genes can lead to interindividual variability in glucuronidation capacity. Age: Newborns and the elderly may have reduced glucuronidation activity, affecting drug metabolism and toxicity. Diet and Lifestyle: Certain dietary components and lifestyle factors can modulate UGT activity, influencing the formation of glucuronides. Drug Interactions: Some drugs can inhibit or induce UGT enzymes, altering glucuronidation rates of co-administered substances.
