biological factors

What Role Does Sex Play in Toxicology?

Sex-based biological differences can influence how an organism responds to a toxicant. Hormonal variations between males and females can affect the absorption, distribution, metabolism, and excretion (ADME) of chemicals. For example, some toxicants may disproportionately affect one sex due to differences in body composition, hormonal regulation, or enzymatic activity. Understanding these differences is essential for developing gender-specific safety guidelines.

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