Several factors can influence the impact of long-term exposure to toxicants. The doseâthe amount of a substance an organism is exposed toâis a critical determinant of toxicity. The duration of exposure, frequency, and the route of exposure (such as inhalation, ingestion, or dermal contact) also play significant roles. Additionally, individual susceptibility due to genetic factors, age, sex, and health status can affect how an organism responds to a toxicant over time.
