Several factors can influence the determination of MTD. These include the route of administration (oral, intravenous, etc.), the age and health status of the test subjects, and the presence of other medications or substances that could interact with the compound. Genetic and environmental factors may also play a role, as they can affect how substances are metabolized and cleared from the body. Additionally, the specific endpoints or toxicities being monitored can influence what is considered a tolerable dose.
