Several factors can influence safe dosage levels, including:
1. Age: Children and the elderly may have different tolerances to substances due to metabolic differences. 2. Weight: Dosage often needs to be adjusted based on body weight to ensure safety. 3. Gender: Hormonal differences can affect how a substance is metabolized. 4. Genetics: Genetic variations can influence individual responses to substances. 5. Health Conditions: Pre-existing conditions such as liver or kidney disease can alter the way a substance is processed in the body. 6. Drug Interactions: Concurrent use of other medications can affect the safety and efficacy of a given dose.