Several factors influence the determination and application of safety thresholds, including:
Age: Children and elderly individuals may have different sensitivities to toxic substances. Genetics: Genetic variations can affect how individuals metabolize and respond to chemicals. Exposure Duration: Short-term versus long-term exposure can result in different health outcomes. Route of Exposure: Ingestion, inhalation, and dermal absorption can lead to different levels of toxicity. Health Status: Preexisting health conditions can make individuals more susceptible to toxic effects.