Why is Non-Linear Pharmacokinetics Important in Toxicology?
Understanding non-linear pharmacokinetics is vital in toxicology for several reasons:
Accurate Dose Prediction: Non-linear kinetics can lead to drug accumulation and toxic effects, making it critical to predict the right dose to avoid toxicity. Therapeutic Drug Monitoring: For drugs with narrow therapeutic windows, monitoring levels is essential to maintain efficacy while preventing adverse effects, particularly when non-linear kinetics are involved. Drug Interactions: Non-linear kinetics can amplify the effects of drug interactions, increasing the risk of toxicity.
