Cumulative Risk Assessment (CRA) is a methodology used in toxicology to evaluate the combined risks posed by multiple toxicants or stressors. Unlike traditional risk assessment, which typically focuses on a single chemical or exposure route, CRA considers the potential for additive, synergistic, or antagonistic effects from multiple chemicals, exposure pathways, and populations. This approach provides a more comprehensive understanding of potential health risks, particularly in complex environments where individuals are exposed to multiple chemicals.