Lupus anticoagulant is an autoantibody associated with the immune system erroneously attacking normal blood proteins. It is a type of antiphospholipid antibody that interferes with the blood clotting process. Despite its name, lupus anticoagulant is not directly linked to lupus, a chronic autoimmune disease. Instead, it is more broadly associated with antiphospholipid syndrome (APS), which increases the risk of thrombosis.