Protein Phosphatase 2A (PP2A) is a major serine/threonine phosphatase in eukaryotic cells, implicated in a wide range of cellular processes including cell growth, division, and signal transduction. PP2A is a heterotrimeric enzyme composed of a catalytic subunit (C), a structural subunit (A), and a regulatory subunit (B). The regulatory subunit determines substrate specificity, localization, and activity of the holoenzyme.