Cells have evolved sophisticated DNA repair mechanisms to address SSBs. The primary pathway for repairing single strand breaks is the base excision repair (BER) pathway. This process involves recognition of the break, removal of damaged bases, and synthesis of new DNA to fill the gap. Key proteins involved in this process include PARP (poly ADP ribose polymerase) and XRCC1 (X-ray repair cross-complementing protein 1).
