What is the Constitutive Androstane Receptor (CAR)?
The Constitutive Androstane Receptor (CAR) is a nuclear receptor that plays a crucial role in the regulation of genes involved in drug metabolism and disposition. CAR is predominantly expressed in the liver and is known for its ability to modulate the expression of various enzymes, including cytochrome P450s, that are essential for the biotransformation of xenobiotics. This makes it a key player in the body's defense mechanism against potentially harmful chemicals.
