The future of rats in toxicology is evolving with advances in scientific techniques. Emerging technologies like CRISPR and other genetic engineering methods allow for more precise manipulation of rat genomes, enhancing the relevance of findings. However, there is also a trend towards reducing reliance on animal testing altogether through the development of alternative models. As these technologies advance, the role of rats may shift, focusing on areas where they provide unique insights that cannot be replicated by other means.