What is the historical context of Chloroquine use and toxicity?
Chloroquine has been used since the mid-20th century, and its extensive use has led to well-documented cases of drug resistance in malaria-endemic regions. The COVID-19 pandemic brought renewed attention to chloroquine as a potential treatment, leading to increased reports of toxicity due to misuse and overprescription. This highlights the importance of understanding the pharmacokinetics and safety profile of chloroquine.
