What is the Impact of Genetic Variability on Transporters?
Genetic polymorphisms can significantly affect the function of transporter proteins, leading to inter-individual variability in drug response and toxicity. For example, variations in the genes encoding for transporters such as P-glycoprotein or organic cation transporters (OCTs) can alter drug absorption rates, influence blood-brain barrier penetration, and modify the hepatic clearance of xenobiotics. Understanding these genetic differences is crucial for personalized medicine approaches.
