How Do Transporter Proteins Affect Xenobiotic Metabolism?
Certain transporter proteins, such as those in the solute carrier (SLC) family and ATP-binding cassette (ABC) transporters, are involved in the uptake and efflux of xenobiotics. The balance between these processes determines the bioavailability of xenobiotics and their toxicity levels. Transporters like organic anion-transporting polypeptides (OATPs) and multidrug resistance proteins (MRPs) are essential in the metabolism and clearance of potentially harmful substances.
