What is the role of genetic factors in NAPQI toxicity?
Genetic polymorphisms in cytochrome P450 enzymes can influence the metabolism of acetaminophen and the production of NAPQI. Variations in the genes encoding these enzymes can lead to increased production of NAPQI, predisposing individuals to a higher risk of toxicity. Genetic testing and research are ongoing to better understand these interactions and their implications for personalized medicine.
