What Are the Consequences of Impaired Beta Oxidation?
When beta oxidation is impaired, cells may experience:
Energy Deficiency: Reduced production of acetyl-CoA leads to decreased ATP synthesis, which can compromise cell viability and function. Accumulation of Toxic Metabolites: Inhibition of beta oxidation results in the build-up of fatty acids and toxic intermediates, which can disrupt cellular homeostasis. Lipid Storage Disorders: Chronic impairment may lead to lipid accumulation in tissues, contributing to conditions such as non-alcoholic fatty liver disease (NAFLD).
