What is the Role of Pharmacogenomics in Statin Toxicology?
Pharmacogenomics plays a crucial role in understanding individual variability in response to statins. Genetic variations in the SLCO1B1 gene, which encodes for the liver transporter OATP1B1, can affect statin uptake and metabolism, leading to an increased risk of muscle toxicity. Identifying such genetic markers can help tailor statin therapy to minimize adverse effects.
