What is the Role of the Unfolded Protein Response?
The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER). It's activated when there is an accumulation of misfolded or unfolded proteins in the ER. Toxic agents that cause protein misfolding can trigger the UPR, which aims to restore normal function by halting protein translation, degrading misfolded proteins, and activating signaling pathways to increase the production of molecular chaperones.
