What Is the Significance of Lysosomes in the Context of Toxicology?
Lysosomes are cellular organelles containing enzymes for breaking down biomolecules. They play a role in autophagy, a cellular degradation process. Toxins can cause lysosomal membrane permeabilization, releasing enzymes into the cytosol that can lead to cell death. For instance, silica particles are known to induce lysosomal damage.
