Several natural and synthetic compounds have been identified as Nrf2 activators. Some of the most studied include:
- Sulforaphane: Found in cruciferous vegetables like broccoli, sulforaphane is a potent Nrf2 activator known for its protective effects against oxidative stress. - Curcumin: The active compound in turmeric, curcumin has demonstrated the ability to activate Nrf2 and provide anti-inflammatory and antioxidant benefits. - Resveratrol: A polyphenol present in grapes and red wine, resveratrol has been shown to activate Nrf2, contributing to its cardioprotective and anti-aging effects. - Oltipraz: Originally developed as an anti-schistosomal drug, oltipraz is a synthetic compound that acts as an Nrf2 activator, used in research for its chemopreventive properties.
