Tolerable Daily Intake (TDI) is a scientific estimate of the amount of a substance that can be ingested daily over a lifetime without posing a significant risk to health. It is primarily used for chemicals that are not intentionally added to food, such as environmental contaminants and residues. The concept of TDI is crucial in the field of toxicology as it helps in assessing the potential health risks associated with long-term exposure to various substances.