What Makes Grapefruit Extract Toxicologically Relevant?
The primary concern with grapefruit extract in toxicology is its ability to interact with cytochrome P450 enzymes, particularly CYP3A4. These enzymes are crucial for the metabolism of many drugs. Grapefruit extract can inhibit the activity of CYP3A4, leading to increased levels of certain drugs in the bloodstream, which may result in adverse effects.
