Antidotes are specific agents used to counteract the effects of certain poisons. They can work by different mechanisms, such as direct neutralization of the toxin, inhibiting toxic metabolite formation, or enhancing the elimination of the toxin. Examples include N-acetylcysteine for acetaminophen overdose and naloxone for opioid toxicity. The availability and timely administration of antidotes are crucial for the successful management of poisoning cases.