MTHFR plays a pivotal role in the methylation cycle, which is significant for detoxification. Methylation is a biochemical process that involves the transfer of a methyl group to an organic compound, essential for the conversion of toxins into less harmful substances that can be excreted from the body. Individuals with MTHFR polymorphisms may experience reduced methylation capacity, potentially leading to an accumulation of toxins and an increased risk of toxicological implications.