What Role Do Carrier Proteins Play in Drug Resistance?
In toxicology, carrier proteins are often implicated in drug resistance, particularly in cancer treatment. Transporters like P-glycoprotein and MRP (Multidrug Resistance-associated Proteins) actively pump chemotherapeutic agents out of cancer cells, reducing their efficacy. This action not only decreases the drug's potency but also necessitates higher doses, potentially increasing toxicity to the patient.
