What Role Do Genetic Factors Play in Susceptibility to Toxins?
Genetic variability significantly impacts how individuals respond to toxins. Polymorphisms in genes encoding for enzymes involved in the metabolism of toxins, such as CYP450 enzymes, can lead to differences in detoxification efficiency. For example, variations in the GSTM1 gene can alter the detoxification of carcinogens found in tobacco smoke, affecting lung cancer risk.
