How Do Genetic Disorders Affect Detoxification Pathways?
Genetic disorders can impair the body's ability to detoxify harmful substances. For example, individuals with [phenylketonuria]() have a defective PAH gene, leading to the accumulation of phenylalanine, which can cause brain damage. Similarly, mutations in the ALDH2 gene can impair alcohol metabolism, leading to increased acetaldehyde levels and a higher risk of liver damage and cancer.
