What Role Do Signaling Pathways Play in Cell Migration?
Cell migration is tightly regulated by various signaling pathways that coordinate cellular responses to external stimuli. Pathways such as the Rho GTPase, MAPK/ERK, and PI3K/Akt are critical for the regulation of cell movement. Toxicants can alter these signaling pathways, leading to dysfunctional migration. For example, exposure to certain pesticides has been shown to dysregulate the RhoA signaling pathway, affecting cellular motility and adhesion.
