Naltrexone works by binding to the mu-opioid receptors in the brain. These receptors are responsible for the euphoric and pain-relieving effects of opioids. By blocking these receptors, naltrexone prevents opioids from exerting their effects, thus reducing the rewarding sensation associated with opioid use. In the case of alcohol dependence, the exact mechanism is less clear, but it is believed that naltrexone helps modulate the brain's reward system, reducing the craving for alcohol.
