What Role Does Metabolism Play in Substance Interactions?
The metabolism of chemicals is a critical aspect of their toxicity and interactions. Metabolic pathways can activate or deactivate chemicals, influencing their toxic potential. Enzyme induction or inhibition by one chemical can alter the metabolism of another, leading to increased toxicity or reduced efficacy. Cytochrome P450 enzymes are often involved in such interactions, where one chemical may enhance or impede the enzyme's activity, affecting the metabolism of co-exposed substances.
