What Role Does NER Play in Chemotherapy Resistance?
NER is not only crucial in repairing environmental and chemical-induced DNA damage but also plays a significant role in the efficacy of certain chemotherapy drugs. Agents like cisplatin form DNA adducts that are targets for NER. Tumor cells with enhanced NER activity can repair these adducts effectively, leading to resistance against such treatments. Understanding the modulation of NER in cancer cells can aid in developing strategies to overcome chemotherapy resistance.
